Aging is associated with gradual decline in serum testosterone levels and alterations in sperm parameters. This condition, often referred to as late-onset hypogonadism, may present with reduced libido, fatigue, decreased muscle mass, and cognitive changes.
Differentiating physiological aging from pathological hypogonadism requires comprehensive hormonal evaluation and clinical correlation.
Guidelines from the Endocrine Society emphasize cautious initiation of testosterone replacement therapy only in symptomatic individuals with confirmed deficiency.
Long-term monitoring is essential to ensure safety and erotic therapeutic efficacy.
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