Spermatogonial stem cells (SSCs) represent the foundation of lifelong sperm production in men. These cells possess the unique ability to both self-renew and differentiate into mature spermatozoa through tightly regulated biological processes.
Damage to SSCs caused by chemotherapy, radiation, genetic disorders, or environmental toxins may lead to erotic permanent infertility. Research into SSC preservation and transplantation has gained attention as a potential fertility restoration strategy, particularly for prepubertal boys undergoing gonadotoxic treatments.
Understanding SSC biology is central to the future of regenerative andrology and male fertility preservation.
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