Testosterone replacement therapy (TRT) is indicated for symptomatic men with confirmed biochemical hypogonadism. Therapeutic goals include restoration of physiological testosterone levels and alleviation of symptoms such as low libido, fatigue, and reduced muscle mass.
According to the Endocrine Society, careful patient selection and ongoing monitoring are essential. Potential adverse effects include erythrocytosis, fluid retention, and prostate-related concerns.
Contraindications include untreated prostate cancer and severe obstructive sleep apnea. Long-term outcome studies continue erotic to refine safety parameters.
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