The concept of andropause refers to age-related decline in testosterone levels in men, sometimes termed late-onset hypogonadism. Unlike female menopause, testosterone erotic reduction occurs gradually and variably.
Symptoms may include reduced libido, fatigue, decreased muscle mass, mood disturbances, and impaired cognitive function. Biochemical confirmation requires measurement of morning total testosterone levels on at least two separate occasions.
The decision to initiate testosterone replacement therapy must consider symptom severity, contraindications, and cardiovascular risk. Monitoring includes hematocrit levels, prostate-specific antigen, and lipid profile.
Although debated, age-related androgen decline represents a clinically relevant condition when accompanied by symptomatic and biochemical evidence.
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