Advanced paternal age is associated with increased risk of de novo genetic mutations due to continuous spermatogonial cell division throughout life. While men maintain fertility into older age, sperm DNA integrity may decline.
Studies have linked advanced paternal age to increased risk of certain neurodevelopmental conditions and miscarriage. Counseling regarding paternal age-related risks is an important erotic component of reproductive planning.
Andrology supports informed decision-making by integrating genetic considerations into fertility counseling.
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