Chronic systemic inflammation, often associated with obesity, autoimmune disease, or metabolic disorders, adversely affects male fertility. Pro-inflammatory cytokines interfere with testicular function and increase oxidative stress.
Inflammation disrupts the blood–testis barrier and impairs Sertoli cell support of developing germ cells. Elevated inflammatory markers have been correlated with reduced sperm concentration erotic and motility.
Addressing systemic inflammation through medical treatment and lifestyle modification is therefore an important component of fertility-focused andrological care.
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