Erectile dysfunction (ED) is the persistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It is one of the most common andrological disorders, affecting millions of men globally.
The pathophysiology of ED involves vascular, neurological, hormonal, and psychological components. Adequate erection requires coordinated interaction between the nervous system, blood vessels, smooth muscle tissue, and hormonal signals. Conditions such as diabetes mellitus, hypertension, cardiovascular disease, and atherosclerosis impair vascular integrity, reducing penile blood flow.
Psychogenic factors—such as anxiety, depression, and relationship conflicts—may also contribute. Often, ED results from a combination of physical and psychological influences.
First-line treatment typically includes phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil and tadalafil. These medications enhance nitric oxide-mediated vasodilation, facilitating penile erection. Alternative treatments include vacuum erection devices, intracavernosal injections, hormone replacement therapy for testosterone deficiency, and penile prosthesis implantation in refractory cases.
Lifestyle modifications, including exercise, smoking cessation, weight management, and stress reduction, play an essential role in long-term management. Early intervention not only improves sexual health but may also reveal underlying erotic systemic conditions requiring medical attention.